Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3KÎ´) inhibitors.

Xin, Minhang; Duan, Weiming; Feng, Yifan; Hei, Yuan-Yuan; Zhang, Hao; Shen, Ying; Zhao, Hong-Yi; Mao, Shuai; Zhang, San-Qi

Xin, Minhang; Duan, Weiming; Feng, Yifan; Hei, Yuan-Yuan; Zhang, Hao; Shen, Ying; Zhao, Hong-Yi; Mao, Shuai; Zhang, San-Qi.

Afiliação

Xin M; a Department of Medicinal Chemistry, School of Pharmacy , Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.
Duan W; a Department of Medicinal Chemistry, School of Pharmacy , Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.
Feng Y; a Department of Medicinal Chemistry, School of Pharmacy , Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.
Hei YY; a Department of Medicinal Chemistry, School of Pharmacy , Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.
Zhang H; a Department of Medicinal Chemistry, School of Pharmacy , Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.
Shen Y; a Department of Medicinal Chemistry, School of Pharmacy , Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.
Zhao HY; a Department of Medicinal Chemistry, School of Pharmacy , Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.
Mao S; a Department of Medicinal Chemistry, School of Pharmacy , Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.
Zhang SQ; a Department of Medicinal Chemistry, School of Pharmacy , Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.

J Enzyme Inhib Med Chem ; 33(1): 651-656, 2018 Dec.

Article em En | MEDLINE | ID: mdl-29536777

Assuntos

Classe I de Fosfatidilinositol 3-Quinases/antagonistas & inibidores; Piperidinas/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Pirrolidinas/farmacologia; Quinazolinas/farmacologia; Classe I de Fosfatidilinositol 3-Quinases/metabolismo; Relação Dose-Resposta a Droga; Humanos; Estrutura Molecular; Piperidinas/química; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Pirrolidinas/química; Quinazolinas/síntese química; Quinazolinas/química; Relação Estrutura-Atividade

Palavras-chave

4-piperidineamino; 4-pyrrolidineoxy; PI3KÎ´ inhibitors; anti-proliferation; selectivity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Pirrolidinas / Quinazolinas / Inibidores de Proteínas Quinases / Classe I de Fosfatidilinositol 3-Quinases Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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