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An acute functional screen identifies an effective antibody targeting amyloid-ß oligomers based on calcium imaging.
Wang, Xueying; Kastanenka, Ksenia V; Arbel-Ornath, Michal; Commins, Caitlin; Kuzuya, Akira; Lariviere, Amanda J; Krafft, Grant A; Hefti, Franz; Jerecic, Jasna; Bacskai, Brian J.
Afiliação
  • Wang X; Massachusetts General Hospital, Department of Neurology, 114 16th Street, Charlestown, MA, 02129, USA.
  • Kastanenka KV; Harvard University, Center for Brain Science, 52 Oxford Street, Cambridge, MA, 02138, USA.
  • Arbel-Ornath M; Massachusetts General Hospital, Department of Neurology, 114 16th Street, Charlestown, MA, 02129, USA.
  • Commins C; Massachusetts General Hospital, Department of Neurology, 114 16th Street, Charlestown, MA, 02129, USA.
  • Kuzuya A; Massachusetts General Hospital, Department of Neurology, 114 16th Street, Charlestown, MA, 02129, USA.
  • Lariviere AJ; Massachusetts General Hospital, Department of Neurology, 114 16th Street, Charlestown, MA, 02129, USA.
  • Krafft GA; Massachusetts General Hospital, Department of Neurology, 114 16th Street, Charlestown, MA, 02129, USA.
  • Hefti F; Acumen Pharmaceuticals, Inc., 4435 North First Street, #360, Livermore, CA, 94551, USA.
  • Jerecic J; Acumen Pharmaceuticals, Inc., 4435 North First Street, #360, Livermore, CA, 94551, USA.
  • Bacskai BJ; Acumen Pharmaceuticals, Inc., 4435 North First Street, #360, Livermore, CA, 94551, USA. jasna@calsynapse.com.
Sci Rep ; 8(1): 4634, 2018 03 15.
Article em En | MEDLINE | ID: mdl-29545579
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento de Imagem Assistida por Computador / Encéfalo / Cálcio / Peptídeos beta-Amiloides / Doença de Alzheimer / Anticorpos Monoclonais Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged80 / Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento de Imagem Assistida por Computador / Encéfalo / Cálcio / Peptídeos beta-Amiloides / Doença de Alzheimer / Anticorpos Monoclonais Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged80 / Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article