Mammalian nonmuscle myosin II comes in three flavors.
Biochem Biophys Res Commun
; 506(2): 394-402, 2018 11 25.
Article
em En
| MEDLINE
| ID: mdl-29550471
ABSTRACT
Nonmuscle myosin II is an actin-based motor that executes numerous mechanical tasks in cells including spatiotemporal organization of the actin cytoskeleton, adhesion, migration, cytokinesis, tissue remodeling, and membrane trafficking. Nonmuscle myosin II is ubiquitously expressed in mammalian cells as a tissue-specific combination of three paralogs. Recent studies reveal novel specific aspects of their kinetics, intracellular regulation and functions. On the other hand, the three paralogs also can copolymerize and cooperate in cells. Here we review the recent advances from the prospective of how distinct features of the three myosin II paralogs adapt them to perform specialized and joint tasks in the cell.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto de Actina
/
Actinas
/
Cadeias Pesadas de Miosina
/
Miosina Tipo II
/
Miosina não Muscular Tipo IIA
/
Miosina não Muscular Tipo IIB
/
Matriz Extracelular
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article