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Clinical pharmacodynamic/exposure characterisation of the multikinase inhibitor ilorasertib (ABT-348) in a phase 1 dose-escalation trial.
Maitland, Michael L; Piha-Paul, Sarina; Falchook, Gerald; Kurzrock, Razelle; Nguyen, Ly; Janisch, Linda; Karovic, Sanja; McKee, Mark; Hoening, Elizabeth; Wong, Shekman; Munasinghe, Wijith; Palma, Joann; Donawho, Cherrie; Lian, Guinan K; Ansell, Peter; Ratain, Mark J; Hong, David.
Afiliação
  • Maitland ML; Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. Michael.Maitland@inova.org.
  • Piha-Paul S; Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. Michael.Maitland@inova.org.
  • Falchook G; Comprehensive Cancer Center, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. Michael.Maitland@inova.org.
  • Kurzrock R; Inova Schar Cancer Institute, Inova Center for Personalized Health, and Virginia Commonwealth University, 3225 Gallows Road, Falls Church, VA, 22037, USA. Michael.Maitland@inova.org.
  • Nguyen L; Department of Investigational Cancer Therapeutics, The University of Texas, MD Anderson Cancer Center, 1400 Holcombe Boulevard, Unit 455, Faculty Center 8th Floor, Houston, TX, 77030, USA.
  • Janisch L; Sarah Cannon Research Institute at HealthONE, Drug Development, 1800 N Williams Street Suite 300, Denver, CO, 80218, USA.
  • Karovic S; Center for Personalized Cancer Therapy, Moores Cancer Center, The University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, 92093, USA.
  • McKee M; Department of Investigational Cancer Therapeutics, The University of Texas, MD Anderson Cancer Center, 1400 Holcombe Boulevard, Unit 455, Faculty Center 8th Floor, Houston, TX, 77030, USA.
  • Hoening E; Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.
  • Wong S; Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.
  • Munasinghe W; Inova Schar Cancer Institute, Inova Center for Personalized Health, and Virginia Commonwealth University, 3225 Gallows Road, Falls Church, VA, 22037, USA.
  • Palma J; AbbVie Inc., 1 N Waukegan Road, North Chicago, IL, 60064, USA.
  • Donawho C; AbbVie Inc., 1 N Waukegan Road, North Chicago, IL, 60064, USA.
  • Lian GK; AbbVie Inc., 1 N Waukegan Road, North Chicago, IL, 60064, USA.
  • Ansell P; AbbVie Inc., 1 N Waukegan Road, North Chicago, IL, 60064, USA.
  • Ratain MJ; AbbVie Inc., 1 N Waukegan Road, North Chicago, IL, 60064, USA.
  • Hong D; AbbVie Inc., 1 N Waukegan Road, North Chicago, IL, 60064, USA.
Br J Cancer ; 118(8): 1042-1050, 2018 04.
Article em En | MEDLINE | ID: mdl-29551775
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Inibidores de Proteínas Quinases / Aminopiridinas / Neoplasias Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Inibidores de Proteínas Quinases / Aminopiridinas / Neoplasias Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article