Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease.

Kurahara, Lin Hai; Hiraishi, Keizo; Hu, Yaopeng; Koga, Kaori; Onitsuka, Miki; Doi, Mayumi; Aoyagi, Kunihiko; Takedatsu, Hidetoshi; Kojima, Daibo; Fujihara, Yoshitaka; Jian, Yuwen; Inoue, Ryuji

Kurahara, Lin Hai; Hiraishi, Keizo; Hu, Yaopeng; Koga, Kaori; Onitsuka, Miki; Doi, Mayumi; Aoyagi, Kunihiko; Takedatsu, Hidetoshi; Kojima, Daibo; Fujihara, Yoshitaka; Jian, Yuwen; Inoue, Ryuji.

Afiliação

Kurahara LH; Department of Physiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Hiraishi K; Department of Physiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Hu Y; Department of Physiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Koga K; Department of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Onitsuka M; Department of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Doi M; Department of Physiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Aoyagi K; Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine, Oita University, Oita, Japan.
Takedatsu H; Department of Gastroenterology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.
Kojima D; Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Fujihara Y; Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Jian Y; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Inoue R; College of Letters and Science, University of California-Davis, Davis, California.

Cell Mol Gastroenterol Hepatol ; 5(3): 299-318, 2018 Mar.

Article em En | MEDLINE | ID: mdl-29552620

Palavras-chave

AITC, allyl isothiocyanate; CD, Crohn's disease; Crohn's Disease; EGTA, ethylene glycol-bis(ß-aminoethyl ether)-N,N,N',N'-tetraacetic acid; HSP47, heat shock protein 47; InMyoFib, intestinal myofibroblast cell line; Intestinal Fibrosis; KO, knockout; MT, Masson trichrome; Myofibroblast; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; RT-PCR, reverse-transcription polymerase chain reaction; TGF, transforming growth factor; TNBS, trinitrobenzene sulfonic acid; TNF, tumor necrosis factor; TRP, transient receptor potential; TRPA1, transient receptor potential ankyrin 1; TRPC, transient receptor potential canonical; Transient Receptor Potential Ankyrin 1; WT, wild-type; mRNA, messenger RNA; sgRNA, single-guide RNA; siRNA, small interfering RNA; α-SMA, α smooth muscle actin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article