Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis.
J Nat Prod
; 81(4): 1089-1092, 2018 04 27.
Article
em En
| MEDLINE
| ID: mdl-29553734
ABSTRACT
Sesterterpenes are usually found in plants and fungi, but are rare in bacteria. Here, we present the identification of StsC from Streptomyces somaliensis, a member of the UbiA superfamily, as a membrane-bound sesterterpene cyclase in bacteria. The cyclized products for StsC, somaliensenes A (1) and B (2), were identified by expressing the corresponding gene in an engineered Escherichia coli strain. The structures of 1 and 2 were determined by analysis of the NMR and MS spectroscopic data.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Sesterterpenos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article