PPARß/δ: A Key Therapeutic Target in Metabolic Disorders.
Int J Mol Sci
; 19(3)2018 Mar 20.
Article
em En
| MEDLINE
| ID: mdl-29558390
ABSTRACT
Research in recent years on peroxisome proliferator-activated receptor (PPAR)ß/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARß/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARß/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPARß/δ as a treatment for human metabolic disorders.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
PPAR beta
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PPAR delta
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Doenças Metabólicas
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article