Effects of low concentrations of ibuprofen on freshwater fish Rhamdia quelen.
Environ Toxicol Pharmacol
; 59: 105-113, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29558665
ABSTRACT
Ibuprofen is a pharmaceutical drug widely used by the global population and it has been found in aquatic ecosystems in several countries. This study evaluated the effects of ibuprofen in environmental concentrations (0, 0.1, 1 and 10⯵g/L) on the freshwaterspecies Rhamdia quelen exposed for 14 days. In the posterior kidney, ibuprofen increased glutathione-S-transferase activity in all groups exposed. Furthermore, increased glutathione peroxidase activity and the levels of reduced glutathione in the group exposed to 10⯵g/L. Ibuprofen decreased the carbonic anhydrase activity in the posterior kidney in all exposed groups, and increased the activity in the gills in group exposed to 0.1⯵g/L. The levels of plasma magnesium increased in groups exposed to 0.1 and 1⯵g/L. In the blood, ibuprofen decreased the white blood cell count in groups exposed to 0.1 e 1.0⯵g/L. Therefore, these results indicated that ibuprofen caused nephrotoxicity and demonstrated immunosuppressive effect in Rhamdia quelen.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
/
Peixes-Gato
/
Ibuprofeno
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article