New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.

Gay, Marion; Carato, Pascal; Coevoet, Mathilde; Renault, Nicolas; Larchanché, Paul-Emmanuel; Barczyk, Amélie; Yous, Saïd; Buée, Luc; Sergeant, Nicolas; Melnyk, Patricia

Gay, Marion; Carato, Pascal; Coevoet, Mathilde; Renault, Nicolas; Larchanché, Paul-Emmanuel; Barczyk, Amélie; Yous, Saïd; Buée, Luc; Sergeant, Nicolas; Melnyk, Patricia.

Afiliação

Gay M; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France.
Carato P; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France.
Coevoet M; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France.
Renault N; Univ. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France.
Larchanché PE; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France.
Barczyk A; Univ. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France.
Yous S; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France.
Buée L; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France.
Sergeant N; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France.
Melnyk P; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France. Electronic address: patricia.melnyk@univ-lille2.fr.

Bioorg Med Chem ; 26(8): 2151-2164, 2018 05 01.

Article em En | MEDLINE | ID: mdl-29559198

Assuntos

Precursor de Proteína beta-Amiloide/metabolismo; Compostos de Anilina/metabolismo; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Amodiaquina/química; Amodiaquina/metabolismo; Peptídeos beta-Amiloides/química; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/antagonistas & inibidores; Compostos de Anilina/química; Compostos de Anilina/farmacologia; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Cloroquina/química; Cloroquina/metabolismo; Humanos; Ligação Proteica; Relação Estrutura-Atividade

Palavras-chave

Abeta peptides; Amyloid; Phenylanilines; Polyamines

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Precursor de Proteína beta-Amiloide / Compostos de Anilina Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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