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Contrasting features of childhood and adolescent melanomas.
Bartenstein, Diana W; Kelleher, Cassandra M; Friedmann, Alison M; Duncan, Lyn M; Tsao, Hensin; Sober, Arthur J; Hawryluk, Elena B.
Afiliação
  • Bartenstein DW; School of Medicine, Harvard University, Boston, MA, USA.
  • Kelleher CM; School of Medicine, Tufts University, Boston, MA, USA.
  • Friedmann AM; Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
  • Duncan LM; School of Medicine, Harvard University, Boston, MA, USA.
  • Tsao H; Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA.
  • Sober AJ; School of Medicine, Harvard University, Boston, MA, USA.
  • Hawryluk EB; Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA, USA.
Pediatr Dermatol ; 35(3): 354-360, 2018 May.
Article em En | MEDLINE | ID: mdl-29569376
ABSTRACT
BACKGROUND/

OBJECTIVES:

Melanoma in children and adolescents is uncommon, and there are limited data on pediatric outcomes. Several studies have shown comparable survival rates in children and adults, but other research demonstrates that prepubescent children have more favorable outcomes. This study aims to compare childhood and adolescent melanoma.

METHODS:

Retrospective cohort study of children who received a melanoma diagnosis at the Massachusetts General Hospital between January 1, 1995, and December 21, 2016. Childhood melanoma is defined as disease occurring in patients younger than 11 years old, and adolescent melanoma is defined as disease occurring in patients 11 to 19 years old. Patients diagnosed with ocular melanoma and borderline tumors of uncertain malignant potential were excluded. This analysis compares clinical, histopathologic, and outcome characteristics of childhood and adolescent melanoma.

RESULTS:

Thirty-two children with melanoma were identified (12 children, 20 adolescents). The spitzoid melanoma subtype was significantly more common in children (6/12) than adolescents (2/20) (P = .01). Four adolescents and no children with melanoma died from melanoma, and survival was significantly different between the age groups (P = .04). Median follow-up time for survivors was 3.6 years.

CONCLUSIONS:

These results suggest that children and adolescents present with different melanoma subtypes and that adolescents have a more aggressive disease course than children.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Melanoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Melanoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article