Unexpected involvement of IL-13 signalling via a STAT6 independent mechanism during murine IgG2a development following viral vaccination.

Hamid, Megat Abd; Jackson, Ronald James; Roy, Sreeja; Khanna, Mayank; Ranasinghe, Charani

Hamid, Megat Abd; Jackson, Ronald James; Roy, Sreeja; Khanna, Mayank; Ranasinghe, Charani.

Afiliação

Hamid MA; Molecular Mucosal Vaccine Immunology Group, Department of Immunology and infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Jackson RJ; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Roy S; Molecular Mucosal Vaccine Immunology Group, Department of Immunology and infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Khanna M; Molecular Mucosal Vaccine Immunology Group, Department of Immunology and infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Ranasinghe C; Molecular Mucosal Vaccine Immunology Group, Department of Immunology and infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

Eur J Immunol ; 48(7): 1153-1163, 2018 07.

Article em En | MEDLINE | ID: mdl-29569714

Assuntos

Avipoxvirus/fisiologia; Subunidade alfa2 de Receptor de Interleucina-13/imunologia; Interleucina-13/metabolismo; Interleucina-4/metabolismo; Infecções por Poxviridae/imunologia; Linfócitos T Auxiliares-Indutores/imunologia; Vacinas Virais/imunologia; Animais; Anticorpos Antivirais/metabolismo; Células Cultivadas; Switching de Imunoglobulina; Imunoglobulina G/metabolismo; Isotipos de Imunoglobulinas/metabolismo; Interleucina-13/genética; Subunidade alfa2 de Receptor de Interleucina-13/genética; Interleucina-4/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Fator de Transcrição STAT6/genética; Fator de Transcrição STAT6/metabolismo; Transdução de Sinais; Vacinas Virais/genética

Palavras-chave

Antibody differentiation; IL-13; IL-13Rα2; STAT6; Tfh

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas Virais / Interleucina-4 / Linfócitos T Auxiliares-Indutores / Avipoxvirus / Infecções por Poxviridae / Interleucina-13 / Subunidade alfa2 de Receptor de Interleucina-13 Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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