Higher susceptibility to osmolality of the medaka (Oryzias latipes) mutants in orthologue genes of mammalian skin transglutaminases.
Biosci Biotechnol Biochem
; 82(7): 1165-1168, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29570037
ABSTRACT
Transglutaminase (TG) is an essential enzyme to catalyze cross-linking reactions of epidermal proteins. Recently, we biochemically characterized human skin TG orthologues for medaka (Oryzias latipes), a model fish. By genome editing, gene-modified fishes for the two orthologues were obtained, both of which lack the ordinal enzymes. These fish appeared to exhibit higher susceptibility to osmolality at the period of larvae.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Concentração Osmolar
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Pele
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Oryzias
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Transglutaminases
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Proteínas de Peixes
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Mutação
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article