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Isoflurane Impacts Murine Melanoma Growth in a Sex-Specific, Immune-Dependent Manner: A Brief Report.
Meier, Angela; Gross, Emilie T E; Schilling, Jan M; Seelige, Ruth; Jung, Yujin; Santosa, Endi; Searles, Stephen; Lin, Tuo; Tu, Xin M; Patel, Hemal H; Bui, Jack D.
Afiliação
  • Meier A; From the Departments of Anesthesiology.
  • Gross ETE; Pathology, University of California San Diego, San Diego, California.
  • Schilling JM; From the Departments of Anesthesiology.
  • Seelige R; Department of Veterinary Affairs, San Diego Health Care System, San Diego, California.
  • Jung Y; Pathology, University of California San Diego, San Diego, California.
  • Santosa E; Pathology, University of California San Diego, San Diego, California.
  • Searles S; Pathology, University of California San Diego, San Diego, California.
  • Lin T; Pathology, University of California San Diego, San Diego, California.
  • Tu XM; Department of Family Medicine and Public Health, University of California San Diego, San Diego, California.
  • Patel HH; Department of Family Medicine and Public Health, University of California San Diego, San Diego, California.
  • Bui JD; From the Departments of Anesthesiology.
Anesth Analg ; 126(6): 1910-1913, 2018 06.
Article em En | MEDLINE | ID: mdl-29570154
ABSTRACT
The impact of volatile anesthetics on cancer progression has been observed for decades, but sex differences have not been described. Male and female immune systems vary considerably, and the immune system plays an important role in limiting cancer growth. Currently, mouse models describing the impact of volatile anesthetics on cancer growth are limited to same-sex models. In this brief report, we describe a sex-specific impact of isoflurane on melanoma growth observed in wild-type but not in immune-deficient mice. Future experimental designs related to anesthesia and cancer should evaluate the biological variable of sex in a systematic manner.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caracteres Sexuais / Anestésicos Inalatórios / Imunidade Celular / Isoflurano / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caracteres Sexuais / Anestésicos Inalatórios / Imunidade Celular / Isoflurano / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article