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Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice.
Tsai, Ming-Shiun; Wang, Ying-Han; Lai, Yan-Yun; Tsou, Hsi-Kai; Liou, Gan-Guang; Ko, Jiunn-Liang; Wang, Sue-Hong.
Afiliação
  • Tsai MS; Department of BioIndustry Technology, Da-Yeh University, Taiwan, ROC.
  • Wang YH; Department of Biomedical Sciences, Chung Shan Medical University, Taiwan, ROC.
  • Lai YY; Department of Biomedical Sciences, Chung Shan Medical University, Taiwan, ROC.
  • Tsou HK; Functional Neurosurgery Division, Neurological Institute, Taichung Veterans General Hospital, Taiwan, ROC.
  • Liou GG; Institute of Molecular Biology, Academia Sinica, Taiwan, ROC.
  • Ko JL; Institute of Medicine, Chung Shan Medical University, Taiwan, ROC.
  • Wang SH; Department of Biomedical Sciences, Chung Shan Medical University, Taiwan, ROC; Department of Medical Research, Chung Shan Medical University Hospital, Taiwan, ROC. Electronic address: wangsh@csmu.edu.tw.
Toxicol Lett ; 290: 97-109, 2018 Jun 15.
Article em En | MEDLINE | ID: mdl-29574133
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glucuronosiltransferase / Apoptose / Estresse Oxidativo / Citocromo P-450 CYP2E1 / Quempferóis / Lesão Pulmonar Aguda / Inflamação / Acetaminofen Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glucuronosiltransferase / Apoptose / Estresse Oxidativo / Citocromo P-450 CYP2E1 / Quempferóis / Lesão Pulmonar Aguda / Inflamação / Acetaminofen Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article