[EFFECT OF VIOLATIONS OF CARBOHYDRATE METABOLISM ON THE LEVELS OF BIOMARKERS OF INFLAMMATION OF P-SELECTIN AND GALECTIN-3 IN PATIENTS WITH STABLE ANGINA].
Georgian Med News
; (Issue): 48-53, 2018 Feb.
Article
em Ru
| MEDLINE
| ID: mdl-29578422
ABSTRACT
The aim of the study was to study the effect of carbohydrate metabolism disturbances and other factors on the level of new biomarkers of P-selectin and Galectin-3 inflammation in patients with stable angina. The study included 119 patients with angina with or without diabetes mellitus, as well as patients with type 2 diabetes. Patients included in the study were tested in addition to standard methods to determine the levels of new biomarkers of inflammation of P-selectin, Galectin-3 and hs-CRP. The data obtained showed that the levels of P-selectin and Galectin-3 in patients with stable angina are interrelated, but vary significantly at the individual level, with both biomarkers of inflammation not associated with hs-CRP, which creates the prerequisites for the personalization of therapeutic goals in reducing the systemic inflammatory response. A higher level of P-selectin in a subgroup of patients with stable angina with concomitant diabetes mellitus was revealed in comparison with the subgroup of patients with DM without angina (119.9±30.1 and 79.3±38.2 ng/ml, p<0.05, respectively). P-selectin is linked at the level of glycosylated hemoglobin (correlation coefficient = 0.256, p=0.043) and disorders of carbohydrate metabolism. However, the presence of myocardial ischemia influences the activation of the platelet component of inflammation to a greater extent. Galectin-3 was also linked according to the correlation analysis with violations of carbohydrate metabolism. The levels of P-selectin and Galectin-3 in the plasma of patients with angina pectoris were influenced by sex, age of patients and age at which angina was first diagnosed. However, the greatest effect on P-selectin and Galectin-3 levels was exerted by the degree of coronary atherosclerosis and the severity of angina pectoris according to loading test data.
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Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Selectina-P
/
Galectina 3
/
Diabetes Mellitus Tipo 1
/
Diabetes Mellitus Tipo 2
/
Angina Estável
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Humans
/
Middle aged
Idioma:
Ru
Ano de publicação:
2018
Tipo de documento:
Article