[EFFECT OF VIOLATIONS OF CARBOHYDRATE METABOLISM ON THE LEVELS OF BIOMARKERS OF INFLAMMATION OF P-SELECTIN AND GALECTIN-3 IN PATIENTS WITH STABLE ANGINA].

ABSTRACT

The aim of the study was to study the effect of carbohydrate metabolism disturbances and other factors on the level of new biomarkers of P-selectin and Galectin-3 inflammation in patients with stable angina. The study included 119 patients with angina with or without diabetes mellitus, as well as patients with type 2 diabetes. Patients included in the study were tested in addition to standard methods to determine the levels of new biomarkers of inflammation of P-selectin, Galectin-3 and hs-CRP. The data obtained showed that the levels of P-selectin and Galectin-3 in patients with stable angina are interrelated, but vary significantly at the individual level, with both biomarkers of inflammation not associated with hs-CRP, which creates the prerequisites for the personalization of therapeutic goals in reducing the systemic inflammatory response. A higher level of P-selectin in a subgroup of patients with stable angina with concomitant diabetes mellitus was revealed in comparison with the subgroup of patients with DM without angina (119.9±30.1 and 79.3±38.2 ng/ml, p<0.05, respectively). P-selectin is linked at the level of glycosylated hemoglobin (correlation coefficient = 0.256, p=0.043) and disorders of carbohydrate metabolism. However, the presence of myocardial ischemia influences the activation of the platelet component of inflammation to a greater extent. Galectin-3 was also linked according to the correlation analysis with violations of carbohydrate metabolism. The levels of P-selectin and Galectin-3 in the plasma of patients with angina pectoris were influenced by sex, age of patients and age at which angina was first diagnosed. However, the greatest effect on P-selectin and Galectin-3 levels was exerted by the degree of coronary atherosclerosis and the severity of angina pectoris according to loading test data.