Circulating Interleukin-6 is a biomarker for coronary atherosclerosis in nonalcoholic fatty liver disease: Results from the Multi-Ethnic Study of Atherosclerosis.
Int J Cardiol
; 259: 198-204, 2018 05 15.
Article
em En
| MEDLINE
| ID: mdl-29579601
ABSTRACT
BACKGROUND:
Biomarkers to predict the presence and severity of subclinical cardiovascular disease (CVD) in nonalcoholic fatty liver disease (NAFLD) are lacking.METHODS:
3876 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), without known chronic liver disease underwent baseline non-contrast cardiac CT, with NAFLD defined by validated liverspleen ratio (LS)â¯<â¯1.0, and subclinical CVD defined by coronary artery calcium (CAC) scoreâ¯>â¯0. Randomly-selected subgroups underwent detailed inflammatory marker testing, including LpPLA2 mass (Nâ¯=â¯2951), activity (Nâ¯=â¯3020), high-sensitivity C-reactive protein (hsCRP; Nâ¯=â¯3849), and interleukin-6 (IL-6; Nâ¯=â¯3764). Among those with NAFLD, we estimated the prevalence of CACâ¯>â¯0 and CACâ¯>â¯100 for each SD biomarker increase, using multivariable log-binomial regression models adjusted for cardiometabolic risk factors.RESULTS:
Seventeen percent (Nâ¯=â¯668) of participants met the criteria for NAFLD. NAFLD participants were younger (mean age 61⯱â¯10 vs. 63⯱â¯10â¯years, pâ¯<â¯.0001) but more likely to have an elevated BMI (mean 31.1⯱â¯5.5 vs. 28.0⯱â¯5.2â¯kg/m2, pâ¯<â¯.0001), diabetes (22% vs. 11%, pâ¯<â¯.0001), and increased inflammatory biomarkers, including LpPLA2 activity, hsCRP and IL-6 (all pâ¯<â¯.0001). Among NAFLD participants, IL-6 was the only biomarker independently associated with prevalent CACâ¯>â¯0 (PRâ¯=â¯1.06 [1.00-1.11]), or CACâ¯>â¯100 (PRâ¯=â¯1.09 [1.02-1.17]). In contrast, circulating LpPLA2 mass/activity and hsCRP were not associated with either the prevalence or severity of subclinical CVD (all pâ¯>â¯.05).CONCLUSION:
In a large, multi-ethnic population with NAFLD, IL-6 is independently associated with the prevalence and severity of subclinical atherosclerosis. Further research into the longitudinal effects of NAFLD on progressive CVD will determine whether IL-6 is a marker or mediator of NAFLD-related atherosclerosis.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Interleucina-6
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Hepatopatia Gordurosa não Alcoólica
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article