Modeling the effects of lipid peroxidation during ferroptosis on membrane properties.
Sci Rep
; 8(1): 5155, 2018 03 26.
Article
em En
| MEDLINE
| ID: mdl-29581451
ABSTRACT
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid hydroperoxides. There has been significant research on the pathways leading to the accumulation of oxidized lipids, but the downstream effects and how lipid peroxides cause cell death during ferroptosis remain a major puzzle. We evaluated key features of ferroptosis in newly developed molecular dynamics models of lipid membranes to investigate the biophysical consequences of lipid peroxidation, and generated hypotheses about how lipid peroxides contribute to cell death during ferroptosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peroxidação de Lipídeos
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Morte Celular
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Simulação de Dinâmica Molecular
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Bicamadas Lipídicas
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Membranas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article