Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders.
Br J Psychiatry
; 212(5): 318-320, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29587895
ABSTRACT
Antibody-mediated encephalitis has been discussed as one possible cause for isolated psychotic syndromes. Mostly based on serum samples, findings have been controversial. We present the results of a retrospective study of 124 clinically diagnosed psychotic patients without documented relevant neurological symptoms. All were tested for different antineuronal antibodies in cerebrospinal fluid (CSF) while 81 received serum testing. Antineuronal antibodies in CSF were negative across the sample. 3.7% showed low positive serum antibodies. Our findings highlight the importance of a deeper discussion about the relevance of low positive serum antibodies without concurrent findings in CSF or clinical signs for autoimmune encephalitis.Declaration of interestNone.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
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Autoanticorpos
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Receptores de Neurotransmissores
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Proteínas do Tecido Nervoso
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article