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Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial.
Penn-Nicholson, Adam; Tameris, Michele; Smit, Erica; Day, Tracey A; Musvosvi, Munyaradzi; Jayashankar, Lakshmi; Vergara, Julie; Mabwe, Simbarashe; Bilek, Nicole; Geldenhuys, Hendrik; Luabeya, Angelique Kany-Kany; Ellis, Ruth; Ginsberg, Ann M; Hanekom, Willem A; Reed, Steven G; Coler, Rhea N; Scriba, Thomas J; Hatherill, Mark.
Afiliação
  • Penn-Nicholson A; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Tameris M; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Smit E; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Day TA; Infectious Disease Research Institute, Seattle, WA, USA.
  • Musvosvi M; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Jayashankar L; Infectious Disease Research Institute, Seattle, WA, USA.
  • Vergara J; Infectious Disease Research Institute, Seattle, WA, USA.
  • Mabwe S; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Bilek N; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Geldenhuys H; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Luabeya AK; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Ellis R; Aeras, Rockville, MD, USA.
  • Ginsberg AM; Aeras, Rockville, MD, USA.
  • Hanekom WA; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Reed SG; Infectious Disease Research Institute, Seattle, WA, USA.
  • Coler RN; Infectious Disease Research Institute, Seattle, WA, USA.
  • Scriba TJ; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
  • Hatherill M; South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. Electronic address: mark.hatherill@uct.ac.za.
Lancet Respir Med ; 6(4): 287-298, 2018 04.
Article em En | MEDLINE | ID: mdl-29595510
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Vacinas contra a Tuberculose / Imunogenicidade da Vacina Tipo de estudo: Clinical_trials / Guideline Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País como assunto: Africa Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Vacinas contra a Tuberculose / Imunogenicidade da Vacina Tipo de estudo: Clinical_trials / Guideline Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País como assunto: Africa Idioma: En Ano de publicação: 2018 Tipo de documento: Article