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Dual Transforming Growth Factor-ß and Programmed Death-1 Blockade: A Strategy for Immune-Excluded Tumors?
Vanpouille-Box, Claire; Formenti, Silvia C.
Afiliação
  • Vanpouille-Box C; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA. Electronic address: clv2002@med.cornell.edu.
  • Formenti SC; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA. Electronic address: silvia.formenti@med.cornell.edu.
Trends Immunol ; 39(6): 435-437, 2018 06.
Article em En | MEDLINE | ID: mdl-29598848
ABSTRACT
Tumors that elude infiltration by CD8+ T lymphocytes are particularly resistant to multiple forms of treatment, including immune checkpoint blockade. Stromal transforming growth factor (TGF)-ß appears to play a key role in this process, potentially constituting a target for novel combinatorial regimens tackling immune-excluded neoplasms.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Evasão da Resposta Imune Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Evasão da Resposta Imune Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article