Steroidal Constituents from Roots and Rhizomes of Smilacina japonica.
Molecules
; 23(4)2018 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-29601498
ABSTRACT
Four new steroidal constituents (1-4) along with two known steroidal glycosides (5 and 6) were isolated from the roots and rhizomes of Smilacina japonica. Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25S)-5α-spirostan-9(11)-en-3ß, 17α-diol (1); (25S)-5α-spirostan-9(11)-en-3ß, 12ß-diol (2); (25S)-5α-spirostan-9(11)-en-3ß, 17α-diol-3-O-ß-d-glucopyranoside (3); (25S)-5α-spirostan-9(11)-en-3ß, 17α-diol-3-O-ß-d-glucopyranosyl-(1â2)-[ß-d-glucopyranosyl-(1â3)]-ß-d-galactopyranoside (4); japonicoside B (5); and japonicoside C (6). All six compounds showed cytotoxic activity against SMMC-7712, Bel-7402, A549, H460, and K562 human cancer cells.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esteroides
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Rizoma
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Maianthemum
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Neoplasias
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article