PRMT9 promotes hepatocellular carcinoma invasion and metastasis via activating PI3K/Akt/GSK-3ß/Snail signaling.

Jiang, Hai; Zhou, Zhenyu; Jin, Shaowen; Xu, Kang; Zhang, Heyun; Xu, Junyang; Sun, Qing; Wang, Jie; Xu, Junyao

Jiang, Hai; Zhou, Zhenyu; Jin, Shaowen; Xu, Kang; Zhang, Heyun; Xu, Junyang; Sun, Qing; Wang, Jie; Xu, Junyao.

Afiliação

Jiang H; Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Research Center of Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Zhou Z; Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Jin S; Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Research Center of Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Xu K; Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Zhang H; Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Research Center of Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Xu J; Department of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Sun Q; Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Research Center of Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Wang J; Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Xu J; Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Research Center of Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Cancer Sci ; 109(5): 1414-1427, 2018 May.

Article em En | MEDLINE | ID: mdl-29603830

Assuntos

Carcinoma Hepatocelular/patologia; Proteínas F-Box/metabolismo; Neoplasias Hepáticas/patologia; Proteína-Arginina N-Metiltransferases/metabolismo; Transdução de Sinais; Regulação para Cima; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Linhagem Celular Tumoral; Transição Epitelial-Mesenquimal; Proteínas F-Box/genética; Feminino; Glicogênio Sintase Quinase 3 beta/metabolismo; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Masculino; Invasividade Neoplásica; Metástase Neoplásica; Fosfatidilinositol 3-Quinases/metabolismo; Proteína-Arginina N-Metiltransferases/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fatores de Transcrição da Família Snail; Análise de Sobrevida

Palavras-chave

Akt; PRMT9; hepatocellular carcinoma; invasion; metastasis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Transdução de Sinais / Regulação para Cima / Carcinoma Hepatocelular / Proteínas F-Box / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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