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Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study.
Laetsch, Theodore W; DuBois, Steven G; Mascarenhas, Leo; Turpin, Brian; Federman, Noah; Albert, Catherine M; Nagasubramanian, Ramamoorthy; Davis, Jessica L; Rudzinski, Erin; Feraco, Angela M; Tuch, Brian B; Ebata, Kevin T; Reynolds, Mark; Smith, Steven; Cruickshank, Scott; Cox, Michael C; Pappo, Alberto S; Hawkins, Douglas S.
Afiliação
  • Laetsch TW; University of Texas Southwestern Medical Center/Children's Health, Dallas, TX, USA. Electronic address: ted.laetsch@utsouthwestern.edu.
  • DuBois SG; Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA, USA.
  • Mascarenhas L; Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Turpin B; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Federman N; University of California, Los Angeles, Los Angeles, CA, USA.
  • Albert CM; Seattle Children's Hospital, University of Washington, Fred Hutchinson Cancer Research Center Seattle, WA, USA.
  • Nagasubramanian R; Nemours Children's Hospital, Orlando, FL, USA.
  • Davis JL; Seattle Children's Hospital, University of Washington, Fred Hutchinson Cancer Research Center Seattle, WA, USA.
  • Rudzinski E; Seattle Children's Hospital, University of Washington, Fred Hutchinson Cancer Research Center Seattle, WA, USA.
  • Feraco AM; Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA, USA.
  • Tuch BB; Loxo Oncology Inc, South San Francisco, CA, USA.
  • Ebata KT; Loxo Oncology Inc, South San Francisco, CA, USA.
  • Reynolds M; Loxo Oncology Inc, South San Francisco, CA, USA.
  • Smith S; Loxo Oncology Inc, South San Francisco, CA, USA.
  • Cruickshank S; Loxo Oncology Inc, South San Francisco, CA, USA.
  • Cox MC; Loxo Oncology Inc, South San Francisco, CA, USA.
  • Pappo AS; St Jude Children's Research Hospital, Memphis, TN, USA.
  • Hawkins DS; Seattle Children's Hospital, University of Washington, Fred Hutchinson Cancer Research Center Seattle, WA, USA.
Lancet Oncol ; 19(5): 705-714, 2018 05.
Article em En | MEDLINE | ID: mdl-29606586
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Biomarcadores Tumorais / Receptores Proteína Tirosina Quinases / Inibidores de Proteínas Quinases / Fusão Gênica / Neoplasias / Antineoplásicos Tipo de estudo: Clinical_trials / Guideline / Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: America do norte Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Biomarcadores Tumorais / Receptores Proteína Tirosina Quinases / Inibidores de Proteínas Quinases / Fusão Gênica / Neoplasias / Antineoplásicos Tipo de estudo: Clinical_trials / Guideline / Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: America do norte Idioma: En Ano de publicação: 2018 Tipo de documento: Article