Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice.
Nat Genet
; 50(4): 483-486, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29610476
ABSTRACT
The functional impact of most genomic alterations found in cancer, alone or in combination, remains largely unknown. Here we integrate tumor barcoding, CRISPR/Cas9-mediated genome editing and ultra-deep barcode sequencing to interrogate pairwise combinations of tumor suppressor alterations in autochthonous mouse models of human lung adenocarcinoma. We map the tumor suppressive effects of 31 common lung adenocarcinoma genotypes and identify a landscape of context dependence and differential effect strengths.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Genes Supressores de Tumor
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Adenocarcinoma de Pulmão
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Neoplasias Pulmonares
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article