A high-affinity subtype-selective fluorescent probe for estrogen receptor ß imaging in living cells.
Chem Commun (Camb)
; 54(31): 3887-3890, 2018 Apr 12.
Article
em En
| MEDLINE
| ID: mdl-29610818
ABSTRACT
Estrogen receptor ß (ERß) has recently been identified as a pharmaceutical target in hormone replacement therapy for breast cancers. However, the biological function of ERß in disease progression remains unclear. A highly ERß-selective fluorescent probe (FPNM) was discovered exhibiting nanomolar affinity for ERß with an ERß/ERα selectivity as high as 80, which allowed specific labeling of intracellular ERß. Moreover, distinct ERß dynamics in various cellular bio-settings such as prostate cancer (DU-145) or triple-negative breast cancer (MDA-MB-231) cells were directly observed for the first time viaFPNM staining.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptor beta de Estrogênio
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Corantes Fluorescentes
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Naftalenos
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Nitrilas
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article