Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia.

Wang, Fan; Demir, Salih; Gehringer, Franziska; Osswald, Clarissa D; Seyfried, Felix; Enzenmüller, Stefanie; Eckhoff, Sarah M; Maier, Thomas; Holzmann, Karlheinz; Debatin, Klaus-Michael; Wirth, Thomas; Meyer, Lüder H; Ushmorov, Alexey

Wang, Fan; Demir, Salih; Gehringer, Franziska; Osswald, Clarissa D; Seyfried, Felix; Enzenmüller, Stefanie; Eckhoff, Sarah M; Maier, Thomas; Holzmann, Karlheinz; Debatin, Klaus-Michael; Wirth, Thomas; Meyer, Lüder H; Ushmorov, Alexey.

Afiliação

Wang F; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Demir S; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Gehringer F; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Osswald CD; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Seyfried F; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Enzenmüller S; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Eckhoff SM; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Maier T; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Holzmann K; Core Facility Genomics, University of Ulm, Ulm, Germany.
Debatin KM; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Wirth T; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany.
Meyer LH; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Ushmorov A; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany.

Blood ; 131(26): 2929-2942, 2018 06 28.

Article em En | MEDLINE | ID: mdl-29622548

Assuntos

Proteína Forkhead Box O1/genética; Regulação Leucêmica da Expressão Gênica; Leucemia-Linfoma Linfoblástico de Células Precursoras B/genética; Animais; Antineoplásicos/uso terapêutico; Linfócitos B/efeitos dos fármacos; Linfócitos B/metabolismo; Linfócitos B/patologia; Linhagem Celular Tumoral; Ciclina D3/genética; Proteína Forkhead Box O1/antagonistas & inibidores; Proteína Forkhead Box O1/metabolismo; Regulação Leucêmica da Expressão Gênica/efeitos dos fármacos; Humanos; Camundongos Endogâmicos NOD; Camundongos SCID; Leucemia-Linfoma Linfoblástico de Células Precursoras B/tratamento farmacológico; Leucemia-Linfoma Linfoblástico de Células Precursoras B/metabolismo; Leucemia-Linfoma Linfoblástico de Células Precursoras B/patologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Quinolonas/uso terapêutico; Transdução de Sinais/efeitos dos fármacos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Regulação Leucêmica da Expressão Gênica / Proteína Forkhead Box O1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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