Sildenafil protective effects on high glucose-induced neurotoxicity in PC12 cells: the role of oxidative stress, apoptosis, and inflammation pathways in an in vitro cellular model for diabetic neuropathy.

Saberi Firouzi, Saeedeh; Namazi Sarvestani, Nazanin; Bakhtiarian, Azam; Ghazi Khansari, Mahmoud; Karimi, Mohammad Yahya; Ranjbar, Akram; Safa, Majid; Hosseini, Asieh

Saberi Firouzi, Saeedeh; Namazi Sarvestani, Nazanin; Bakhtiarian, Azam; Ghazi Khansari, Mahmoud; Karimi, Mohammad Yahya; Ranjbar, Akram; Safa, Majid; Hosseini, Asieh.

Afiliação

Saberi Firouzi S; a Faculty of Medicine, Department of Pharmacology , Tehran University of Medical Sciences , Tehran , Iran.
Namazi Sarvestani N; b Department of Animal Biology, School of Biology, Department of Science , University of Tehran , Tehran , Iran.
Bakhtiarian A; a Faculty of Medicine, Department of Pharmacology , Tehran University of Medical Sciences , Tehran , Iran.
Ghazi Khansari M; a Faculty of Medicine, Department of Pharmacology , Tehran University of Medical Sciences , Tehran , Iran.
Karimi MY; c Razi Drug Research Center , Iran University of Medical Sciences , Tehran , Iran.
Ranjbar A; d Department of Toxicology and Pharmacology, School of Pharmacy , Hamadan University of Medical Sciences , Hamadan , Iran.
Safa M; e Faculty of Allied Medicine, Cellular and Molecular Research Center and Department of Hematology and blood banking , Iran University of Medical Sciences , Tehran , Iran.
Hosseini A; c Razi Drug Research Center , Iran University of Medical Sciences , Tehran , Iran.

Neurol Res ; 40(8): 624-636, 2018 Aug.

Article em En | MEDLINE | ID: mdl-29623781

Assuntos

Neuropatias Diabéticas/tratamento farmacológico; Glucose/toxicidade; Fármacos Neuroprotetores/farmacologia; Citrato de Sildenafila/farmacologia; Animais; Apoptose/efeitos dos fármacos; Apoptose/fisiologia; Sobrevivência Celular/efeitos dos fármacos; Sobrevivência Celular/fisiologia; Neuropatias Diabéticas/metabolismo; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Peroxidação de Lipídeos/efeitos dos fármacos; Peroxidação de Lipídeos/fisiologia; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Potencial da Membrana Mitocondrial/fisiologia; Estresse Oxidativo/efeitos dos fármacos; Estresse Oxidativo/fisiologia; Células PC12; Ratos; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Diabetic neuropathy; PC12 cells; apoptosis; high glucose; inflammation; neurotoxicity; oxidative stress; sildenafil

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Neuropatias Diabéticas / Citrato de Sildenafila / Glucose Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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