Prenatal Development and Adolescent Obesity: Two Distinct Pathways to Diabetes in Adulthood.
Child Obes
; 14(3): 173-181, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29624412
ABSTRACT
OBJECTIVE:
Higher body-mass index (BMI) and lower birth weight (BW) are associated with elevated risk of diabetes in adulthood, but the extent to which they compose two distinct pathways is unclear.METHODS:
We used data from the National Longitudinal Study of Adolescent to Adult Health, a cohort of adolescents (1994-1995) followed for 14 years over four waves into adulthood (n = 13,413). Sex-stratified path analysis was used to examine pathways from BW [kg; linear (BW) and quadratic (BW2)] to latent trajectories in BMI from adolescence to adulthood to prevalent diabetes or prediabetes (pre/diabetes) in adulthood, adjusting for sociodemographic characteristics.RESULTS:
Two pathways from BW to pre/diabetes were characterized one from higher BW to elevated BMI and pre/diabetes and a second from lower BW, independent of BMI. In the BMI-independent pathway, greater BW was associated with marginally lower odds of pre/diabetes in women, but not men. Girls born at lower and higher BW exhibited elevated BMI in adolescence [coeff (95% CI) BW -2.1 (-4.1, -0.05); BW2 0.43 (0.09, 0.76)]; higher BW predicted marginally faster BMI gain and higher adolescent BMI and faster BMI gain were associated with pre/diabetes [coeff (95% CI) BMI intercept 0.09 (0.06, 0.11); BMI slope 0.11 (0.07, 0.15)]. In boys, BW was weakly associated with BMI intercept and slope; BMI slope, but not BMI intercept, was positively associated with pre/diabetes [coeff (95% CI) 0.29 (0.19, 0.39)].CONCLUSIONS:
Findings suggest that in girls, slowing BMI gain is critical for diabetes prevention, yet it may not address distinct pathology stemming from early life.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido de Baixo Peso
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Desenvolvimento Fetal
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Diabetes Mellitus
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Obesidade Infantil
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Pregnancy
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article