TSPA as a novel ATF6&#945; translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice.

Zhou, Tingting; Cheng, Yanhua; Yan, Wenzhong; Shi, Xiaofan; Xu, Xin; Zhou, Jinpei; Li, Jian; Chen, Jing; Shen, Xu

TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice.

Zhou, Tingting; Cheng, Yanhua; Yan, Wenzhong; Shi, Xiaofan; Xu, Xin; Zhou, Jinpei; Li, Jian; Chen, Jing; Shen, Xu.

Afiliação

Zhou T; Wuxi School of Medicine, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Cheng Y; School of Pharmacy, China Pharmaceutical University, Jiangsu, Nanjing 210009, China.
Yan W; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Shi X; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Xu X; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhou J; School of Pharmacy, China Pharmaceutical University, Jiangsu, Nanjing 210009, China.
Li J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address: jianli@ecust.edu.cn.
Chen J; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: jingchen@simm.ac.cn.
Shen X; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanj

Biochem Biophys Res Commun ; 499(4): 948-953, 2018 05 23.

Article em En | MEDLINE | ID: mdl-29626480

Assuntos

Acetamidas/farmacologia; Fator 6 Ativador da Transcrição/metabolismo; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Glucose/metabolismo; Homeostase; Resistência à Insulina; Pirazóis/farmacologia; Triazóis/farmacologia; Animais; Linhagem Celular Tumoral; Núcleo Celular/efeitos dos fármacos; Núcleo Celular/metabolismo; Retículo Endoplasmático/efeitos dos fármacos; Retículo Endoplasmático/metabolismo; Humanos; Masculino; Camundongos; Transporte Proteico/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais/efeitos dos fármacos; Fator de Transcrição CHOP/metabolismo; Tunicamicina/farmacologia; Proteína 1 de Ligação a X-Box/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

ATF6α; ER stress; Insulin resistance; T2DM; TSPA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Triazóis / Resistência à Insulina / Diabetes Mellitus Experimental / Fator 6 Ativador da Transcrição / Glucose / Homeostase / Acetamidas Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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