Estradiol stimulates a uterine plasma membrane protease activator.
Endocrinology
; 122(2): 500-3, 1988 Feb.
Article
em En
| MEDLINE
| ID: mdl-2962850
An estrogen-regulated arginine esteropeptidase is present in the immature rat uterus. The enzymatic complex consists of a membrane-bound activator and a soluble proenzyme. The activator is under strong estrogen control; its activity increases 10-fold 3 h after a single dose of 17 beta-estradiol. The subcellular localization of the activator is determined by a radioactive assay of fractions prepared by sucrose density centrifugation. The distribution of activity parallels the distribution of two plasma membrane markers, Mg2+-ATPase and 5'-nucleotidase. Electron micrographic visualization of the gradient fractions containing the activator reveals a population of vesicles 0.2-0.5 micron in diameter.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeo Hidrolases
/
Útero
/
Estradiol
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article