Isolation of a cDNA probe for a human jejunal brush-border hydrolase, sucrase-isomaltase, and assignment of the gene locus to chromosome 3.
Gene
; 57(1): 101-10, 1987.
Article
em En
| MEDLINE
| ID: mdl-2962903
ABSTRACT
We report the nucleotide sequence and derived amino acid sequence of a cDNA clone encoding most of the N-terminal, isomaltase region of human sucrase-isomaltase (SI). A plasmid containing this cDNA, pS12, identifies a 6-kb mRNA found in human jejunum and the human colon carcinoma cell line Caco-2. This human SI cDNA shows extensive overall homology with recently published rabbit SI cDNA. Using pS12 to probe DNA from a panel of somatic cell hybrids, we have assigned the gene encoding human SI to chromosome 3.
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Base de dados:
MEDLINE
Assunto principal:
Complexo Sacarase-Isomaltase
/
Cromossomos Humanos Par 3
/
DNA
/
Genes
/
Jejuno
/
Microvilosidades
/
Complexos Multienzimáticos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article