Gene expression profile associated with postnatal development of pyramidal neurons in the human prefrontal cortex implicates ubiquitin ligase E3 in the pathophysiology of schizophrenia onset.

Kohlbrenner, Emily A; Shaskan, Noel; Pietersen, Charmaine Y; Sonntag, Kai-C; Woo, Tsung-Ung W

Kohlbrenner, Emily A; Shaskan, Noel; Pietersen, Charmaine Y; Sonntag, Kai-C; Woo, Tsung-Ung W.

Afiliação

Kohlbrenner EA; Laboratory for Cellular Neuropathology, Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA; Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA.
Shaskan N; Laboratory for Cellular Neuropathology, Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA; Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA.
Pietersen CY; Laboratory for Cellular Neuropathology, Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA; Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA.
Sonntag KC; Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, 02215, USA.
Woo TW; Laboratory for Cellular Neuropathology, Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA; Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA; Department of Psychiatry

J Psychiatr Res ; 102: 110-117, 2018 07.

Article em En | MEDLINE | ID: mdl-29635114

Assuntos

Córtex Pré-Frontal/patologia; Células Piramidais/metabolismo; Esquizofrenia/patologia; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo; Regulação para Cima/genética; Adolescente; Autopsia; Criança; Pré-Escolar; Feminino; Redes Reguladoras de Genes; Humanos; Masculino; Análise em Microsséries; Córtex Pré-Frontal/crescimento & desenvolvimento; Córtex Pré-Frontal/metabolismo; Análise de Componente Principal; RNA Mensageiro/metabolismo; Transcriptoma; Adulto Jovem

Palavras-chave

Adolescence; Prefrontal cortex; Schizophrenia; Synaptic pruning; Ubiquitin ligase

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Regulação para Cima / Córtex Pré-Frontal / Células Piramidais / Ubiquitina-Proteína Ligases Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google