Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures.
Nephrol Dial Transplant
; 33(9): 1514-1525, 2018 09 01.
Article
em En
| MEDLINE
| ID: mdl-29635428
ABSTRACT
Background:
Vascular endothelial growth factor A (VEGF) is an essential growth factor during glomerular development and postnatal homeostasis. VEGF is secreted in high amounts by podocytes into the primary urine, back-filtered across the glomerular capillary wall to act on endothelial cells. So far it has been assumed that VEGF back-filtration is driven at a constant rate exclusively by diffusion.Methods:
In the present work, glomerular VEGF back-filtration was investigated in vivo using a novel extended model based on endothelial fenestrations as surrogate marker for local VEGF concentrations. Single nephron glomerular filtration rate (SNGFR) and/or local filtration flux were manipulated by partial renal mass ablation, tubular ablation, and in transgenic mouse models of systemic or podocytic VEGF overexpression or reduction.Results:
Our study shows positive correlations between VEGF back-filtration and SNGFR as well as effective filtration rate under physiological conditions along individual glomerular capillaries in rodents and humans.Conclusion:
Our results suggest that an additional force drives VEGF back-filtration, potentially regulated by SNGFR.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Capilares
/
Fator A de Crescimento do Endotélio Vascular
/
Taxa de Filtração Glomerular
/
Glomérulos Renais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article