Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies.
Annu Rev Neurosci
; 41: 207-232, 2018 07 08.
Article
em En
| MEDLINE
| ID: mdl-29641939
ABSTRACT
Brain tumors are the leading cause of cancer-related death in children, and medulloblastoma (MB) is the most common malignant pediatric brain tumor. Advances in surgery, radiation, and chemotherapy have improved the survival of MB patients. But despite these advances, 25-30% of patients still die from the disease, and survivors suffer severe long-term side effects from the aggressive therapies they receive. Although MB is often considered a single disease, molecular profiling has revealed a significant degree of heterogeneity, and there is a growing consensus that MB consists of multiple subgroups with distinct driver mutations, cells of origin, and prognosis. Here, we review recent progress in MB research, with a focus on the genes and pathways that drive tumorigenesis, the animal models that have been developed to study tumor biology, and the advances in conventional and targeted therapy.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cerebelares
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Terapia de Alvo Molecular
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Meduloblastoma
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article