Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia.
J Exp Med
; 215(6): 1627-1647, 2018 06 04.
Article
em En
| MEDLINE
| ID: mdl-29643186
ABSTRACT
Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and during central nervous system (CNS) inflammation. It was initially suggested that these engrafting cells were newly derived microglia and that irradiation was essential for engraftment to occur. However, it remains unclear whether brain-engrafting macrophages (beMφs) acquire a unique phenotype in the brain, whether long-term engraftment may occur without irradiation, and whether brain function is affected by the engrafted cells. In this study, we demonstrate that chronic, partial microglia depletion is sufficient for beMφs to populate the niche and that the presence of beMφs does not alter behavior. Furthermore, beMφs maintain a unique functional and transcriptional identity as compared with microglia. Overall, this study establishes beMφs as a unique CNS cell type and demonstrates that therapeutic engraftment of beMφs may be possible with irradiation-free conditioning regimens.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Microglia
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Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article