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Effects of varying argon ion laser intensity and exposure time on the ablation of atherosclerotic plaque.
Strikwerda, S; Bott-Silverman, C; Ratliff, N B; Goormastic, M; Cothren, R M; Costello, B; Kittrell, C; Feld, M S; Kramer, J R.
Afiliação
  • Strikwerda S; Department of Cardiology, Cleveland Clinic Foundation, OH 44106.
Lasers Surg Med ; 8(1): 66-71, 1988.
Article em En | MEDLINE | ID: mdl-2965289
ABSTRACT
Using continuous wave (CW) argon ion laser light, a total of 253 laser exposures of varying power (1.5, 3, 5, 8 or 10 W) and duration (20-1,333 ms) were delivered to four segments of human atheromatous aorta obtained at autopsy. Exposure conditions were controlled by using an optically shielded laser catheter that provided a 500 micron spot of light of known power. Two thresholds for consistently reproducible ablation could be defined-an intensity threshold at 25.5 W/mm2 and a fluence threshold at 3.2 J/mm2. Above threshold, a fluence of 5.1 J/mm2 was found to produce the most efficient ablation, ie, removed the greatest volume (mm3) per energy delivered (J) compared to other fluence levels employed (p less than 0.0001). Between aortic segments, however, considerable variability in efficiency (mm3/J) was observed, possibly owing to different optical properties and/or plaque composition. Low-intensity laser radiation produced inconsistent ablation and extensive coagulation effects to surrounding tissue. When a fluence of 5.1 J/mm2 was constructed with a high-intensity laser beam and a short exposure time, consistent and efficient tissue removal resulted without histologic evidence of coagulation necrosis.
Assuntos
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Base de dados: MEDLINE Assunto principal: Arteriosclerose / Angioplastia com Balão / Terapia a Laser Limite: Humans Idioma: En Ano de publicação: 1988 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Arteriosclerose / Angioplastia com Balão / Terapia a Laser Limite: Humans Idioma: En Ano de publicação: 1988 Tipo de documento: Article