[Nucleotide polymorphism rs4880 of the SOD2 gene and the risk of male infertility].
Zhonghua Nan Ke Xue
; 23(2): 137-141, 2017 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-29658251
ABSTRACT
OBJECTIVE:
To investigate the correlation of the single nucleotide polymorphism (SNP) rs4880 of the superoxide dismutase 2 (SOD2) gene with the risk of male infertility.METHODS:
This caseîcontrol study included 519 male patients with idiopathic infertility (aged 19ï¼40 ï¼»28.93±4.93ï¼½ years) in the case group and 338 fertile men (aged 19ï¼40 ï¼»28.40±4.25ï¼½ years) in the control group. We collected the clinical data, genotyped the SNP rs4880 of the SOD2 gene by Sequenom Mass Array, and analyzed the association of different genotypes with male infertility using the logistic regression model.RESULTS:
Statically significant differences were observed between the case and control groups in the level of follicleîstimulating hormone (FSH) (ï¼»4.72±2.51ï¼½ vs ï¼»15.65±17.24ï¼½ U/L, P< 0.01), the percentage of progressively mobile sperm (ï¼»9.12±13.5ï¼½ vs ï¼»41.95±9.03ï¼½%, P< 0.01), and sperm concentration (ï¼»12.95±24.38ï¼½ vs ï¼»72.88±45.60ï¼½ ×106/ml, P< 0.01), but not in other parameters. No correlation was found between male infertility and the heterozygous genotype TC (OR = 0.90, 95% CI 0.65ï¼1.25, P = 0.516) or the homozygous genotype CC (OR=1.49, 95% CI 0.38ï¼5.81, P = 0.566) as compared with the wild genotype TT, and similar results were obtained in the analysis of the subgroups.CONCLUSIONS:
The SNP rs4880 of the SOD2 gene was not correlated with male infertility, which, however, is to be supported by further studies with larger samples from more areas.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Polimorfismo de Nucleotídeo Único
/
Infertilidade Masculina
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article