IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors.

Müller, Simon; Bley, Nadine; Glaß, Markus; Busch, Bianca; Rousseau, Vanessa; Misiak, Danny; Fuchs, Tommy; Lederer, Marcell; Hüttelmaier, Stefan

Müller, Simon; Bley, Nadine; Glaß, Markus; Busch, Bianca; Rousseau, Vanessa; Misiak, Danny; Fuchs, Tommy; Lederer, Marcell; Hüttelmaier, Stefan.

Afiliação

Müller S; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.
Bley N; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.
Glaß M; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.
Busch B; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.
Rousseau V; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.
Misiak D; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.
Fuchs T; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.
Lederer M; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.
Hüttelmaier S; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.

Nucleic Acids Res ; 46(12): 6285-6303, 2018 07 06.

Article em En | MEDLINE | ID: mdl-29660014

Assuntos

Regulação Neoplásica da Expressão Gênica; MicroRNAs/metabolismo; Neoplasias/genética; RNA Mensageiro/metabolismo; Proteínas de Ligação a RNA/fisiologia; Animais; Linhagem Celular Tumoral; Regulação para Baixo; Feminino; Deleção de Genes; Humanos; Camundongos Nus; MicroRNAs/antagonistas & inibidores; Neoplasias/metabolismo; Proteínas Oncogênicas/genética; Proteínas Oncogênicas/metabolismo; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/patologia; Fenótipo; Estabilidade de RNA; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Sirtuína 1/genética; Sirtuína 1/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Regulação Neoplásica da Expressão Gênica / Proteínas de Ligação a RNA / MicroRNAs / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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