Pigment epithelium-derived factor/vascular endothelial growth factor ratio plays a crucial role in the spontaneous regression of infant hemangioma and in the therapeutic effect of propranolol.

Zhu, Liuqing; Xie, Jinye; Liu, Zhenyin; Huang, Zhijian; Huang, Mao; Yin, Haofan; Qi, Weiwei; Yang, Zhonghan; Zhou, Ti; Gao, Guoquan; Zhang, Jing; Yang, Xia

Zhu, Liuqing; Xie, Jinye; Liu, Zhenyin; Huang, Zhijian; Huang, Mao; Yin, Haofan; Qi, Weiwei; Yang, Zhonghan; Zhou, Ti; Gao, Guoquan; Zhang, Jing; Yang, Xia.

Afiliação

Zhu L; Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Xie J; Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Liu Z; Program of Molecular Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Huang Z; Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Huang M; Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yin H; Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Qi W; Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yang Z; Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Zhou T; Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Gao G; Department of Biochemistry & Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Zhang J; Program of Molecular Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yang X; Guangdong Engineering & Technology Research Center for Gene Manipulation and Biomacromolecular Products (Sun Yat-sen University), Guangzhou, China.

Cancer Sci ; 109(6): 1981-1994, 2018 Jun.

Article em En | MEDLINE | ID: mdl-29664206

Assuntos

Proteínas do Olho/metabolismo; Hemangioma/tratamento farmacológico; Fatores de Crescimento Neural/metabolismo; Propranolol/uso terapêutico; Serpinas/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Apoptose/efeitos dos fármacos; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/metabolismo; Proteínas do Olho/genética; Proteínas do Olho/farmacologia; Hemangioma/irrigação sanguínea; Hemangioma/metabolismo; Humanos; Lactente; Neovascularização Patológica/metabolismo; Neovascularização Patológica/prevenção & controle; Fatores de Crescimento Neural/genética; Fatores de Crescimento Neural/farmacologia; Receptores de Laminina/genética; Receptores de Laminina/metabolismo; Remissão Espontânea; Serpinas/genética; Serpinas/farmacologia; Fator A de Crescimento do Endotélio Vascular/genética; Fator A de Crescimento do Endotélio Vascular/farmacologia; Receptor 1 de Fatores de Crescimento do Endotélio Vascular/genética; Receptor 1 de Fatores de Crescimento do Endotélio Vascular/metabolismo; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/genética; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo; Vasodilatadores/uso terapêutico

Palavras-chave

angiogenesis; infant hemangioma; pigment epithelium-derived factor; propranolol; vascular endothelial growth factor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propranolol / Serpinas / Fator A de Crescimento do Endotélio Vascular / Proteínas do Olho / Hemangioma / Fatores de Crescimento Neural Limite: Humans / Infant Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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