Decarboxylative Hydroalkylation of Alkynes.
J Am Chem Soc
; 140(17): 5701-5705, 2018 05 02.
Article
em En
| MEDLINE
| ID: mdl-29664294
ABSTRACT
The merger of open- and closed-shell elementary organometallic steps has enabled the selective intermolecular addition of nucleophilic radicals to unactivated alkynes. A range of carboxylic acids can be subjected to a CO2 extrusion, nickel capture, migratory insertion sequence with terminal and internal alkynes to generate stereodefined functionalized olefins. This platform has been further extended, via hydrogen atom transfer, to the direct vinylation of unactivated C-H bonds. Preliminary studies indicate that a Ni-alkyl migratory insertion is operative.
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Base de dados:
MEDLINE
Assunto principal:
Alcenos
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Alcinos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article