CaSiAn: a Calcium Signaling Analyzer tool.
Bioinformatics
; 34(17): 3052-3054, 2018 09 01.
Article
em En
| MEDLINE
| ID: mdl-29668830
ABSTRACT
Summary:
Ca2+ is a central second messenger in eukaryotic cells that regulates many cellular processes. Recently, we have indicated that typical Ca2+ signals are not purely oscillatory as widely assumed, but exhibit stochastic spiking with cell type and pathway specific characteristics. Here, we present the Calcium Signaling Analyzer (CaSiAn), an open source software tool that allows for quantifying these signal characteristics including individual spike properties and time course statistics in a semi-automated manner. CaSiAn provides an intuitive graphical user interface allowing experimentalists to easily process a large amount of Ca2+ signals, interactively tune peak detection, revise statistical measures and access the quantified signal properties as excel or text files. Availability and implementation CaSiAn is implemented in Java and available on Github (https//github.com/mmahsa/CaSiAn) as well as on the project page (http//r3lab.uni.lu/web/casa). Supplementary information Supplementary data are available at Bioinformatics online.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Software
/
Sinalização do Cálcio
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article