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Multiple sclerosis in the Republic of San Marino, Italian peninsula: an incidence and prevalence study from a high-risk area.
Caniglia-Tenaglia, Marta; Guttmann, Susanna; Monaldini, Chiara; Manzaroli, Dario; Volpini, Mirco; Stumpo, Maurizio; Groppo, Elisabetta; Casetta, Ilaria; Govoni, Vittorio; Fonderico, Mattia; Pugliatti, Maura; Granieri, Enrico.
Afiliação
  • Caniglia-Tenaglia M; Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
  • Guttmann S; Unit of Neurology, State Hospital, Cailungo, Republic of San Marino.
  • Monaldini C; Unit of Neurology, State Hospital, Cailungo, Republic of San Marino.
  • Manzaroli D; Unit of Neurology, State Hospital, Cailungo, Republic of San Marino.
  • Volpini M; Unit of Neurology, State Hospital, Cailungo, Republic of San Marino.
  • Stumpo M; Unit of Neurology, State Hospital, Cailungo, Republic of San Marino.
  • Groppo E; Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
  • Casetta I; Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
  • Govoni V; Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
  • Fonderico M; Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
  • Pugliatti M; Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
  • Granieri E; Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy. enrico.granieri@unife.it.
Neurol Sci ; 39(7): 1231-1236, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29671168
ABSTRACT
Epidemiological studies on multiple sclerosis (MS) carried out in Southern Europe in the last years have shown a significant increase in the disease frequency. Previous surveys conducted in the Republic of San Marino, Northern Italian peninsula, identified that the population is at high risk for MS, with a prevalence of 51.6 per 100,000 population in 1982 and of 166.7 in 2005 and with a mean annual incidence of 7.9 per 100,000 for the period 1990-2005. The present work is a community-based intensive prevalence and incidence survey, by a complete enumeration approach, to update the prevalence and incidence of MS in the Republic of San Marino. The mean annual incidence for the period 2005-14 was 7.7 (95% CI 4.9-11.4) per 100,000, 3.3 (95% CI 1.1-7.6) for men and 11.9 (95% CI 7.2-18.6) for women. On 31 December 2014, 67 patients (19 men and 48 women), suffering from definite or probable MS and living in the Republic of San Marino, yielded a crude prevalence of 204.3 (95% CI 158.4-259.5) per 100,000, 117.8 (95% CI 70.9-183.7) for men and 288.2 (95% CI 212.4-383.3) for women. Our study has confirmed San Marino is an area at high risk for MS, in line with epidemiological data from continental Italy. The marked increase in MS prevalence over time in this population can be ascribable to increased survival and improved ascertainment, in the presence of a substantially stable, yet high, incidence rate.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Múltipla Tipo de estudo: Etiology_studies / Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: Europa Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Múltipla Tipo de estudo: Etiology_studies / Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: Europa Idioma: En Ano de publicação: 2018 Tipo de documento: Article