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cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.
Sims, J E; March, C J; Cosman, D; Widmer, M B; MacDonald, H R; McMahan, C J; Grubin, C E; Wignall, J M; Jackson, J L; Call, S M.
Afiliação
  • Sims JE; Immunex Corporation, Seattle, WA 98101.
Science ; 241(4865): 585-9, 1988 Jul 29.
Article em En | MEDLINE | ID: mdl-2969618
ABSTRACT
Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.
Assuntos
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Base de dados: MEDLINE Assunto principal: Receptores Imunológicos / Família Multigênica / Interleucina-1 Limite: Animals Idioma: En Ano de publicação: 1988 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Receptores Imunológicos / Família Multigênica / Interleucina-1 Limite: Animals Idioma: En Ano de publicação: 1988 Tipo de documento: Article