PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.
Cell Mol Life Sci
; 75(15): 2735-2761, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29696344
ABSTRACT
Polarity is a fundamental feature of cells. Protein complexes, including the PAR3-PAR6-aPKC complex, have conserved roles in establishing polarity across a number of eukaryotic cell types. In neurons, polarity is evident as distinct axonal versus dendritic domains. The PAR3, PAR6, and aPKC proteins also play important roles in neuronal polarization. During this process, either aPKC kinase activity, the assembly of the PAR3-PAR6-aPKC complex or the localization of these proteins is regulated downstream of a number of signaling pathways. In turn, the PAR3, PAR6, and aPKC proteins control various effector molecules to establish neuronal polarity. Herein, we discuss the many signaling mechanisms and effector functions that have been linked to PAR3, PAR6, and aPKC during the establishment of neuronal polarity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
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Polaridade Celular
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Proteínas de Ciclo Celular
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Proteínas Adaptadoras de Transdução de Sinal
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Proteínas de Membrana
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Neurônios
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article