Feasibility study of postoperative adjuvant chemotherapy with S-1 in patients with biliary tract cancer.
Int J Clin Oncol
; 23(5): 894-899, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-29705976
ABSTRACT
BACKGROUND:
The role of adjuvant chemotherapy has not yet been established for patients with resected biliary tract cancer. S-1 has been shown to exert activity against advanced biliary tract cancer. Therefore, we evaluated the feasibility of adjuvant chemotherapy with S-1 in patients with resected biliary tract cancer.METHODS:
Patients with complete macroscopic resection of intrahepatic/extrahepatic bile duct, gall bladder, or ampullary cancer were eligible. S-1 was administered orally twice daily for 4 weeks every 6 weeks, up to 4 cycles. The treatment was continued up to 24 weeks or until recurrence/appearance of unacceptable toxicity. The primary endpoint was the treatment completion rate, which was defined as the percentage of patients who received a relative dose intensity of ≥ 75%. This trial was registered as UMIN000004051.RESULTS:
Thirty-three patients were enrolled between June 2010 and March 2011. The relative dose intensity was ≥ 75% in 27 patients representing a treatment completion rate of 81.8%. The most common grade 3/4 adverse event was neutropenia (18%). Grade 2 nausea or diarrhea was observed in 12%. The 3-year relapse-free survival rate was 39.4%. The 3-year survival rate was 54.5%.CONCLUSION:
Adjuvant chemotherapy with S-1 is feasible treatment in patients with resected biliary tract cancer. It is necessary to conduct a phase III study to confirm the efficacy of adjuvant therapy of S-1 in patients with resected BTC.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ácido Oxônico
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Neoplasias do Sistema Biliar
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Carcinoma Papilar
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Tegafur
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Carcinoma de Células em Anel de Sinete
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Recidiva Local de Neoplasia
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Antimetabólitos Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article