GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt-mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway.

Chen, Bih-Cheng; Hung, Meng-Yu; Wang, Hsueh-Fang; Yeh, Li-Jen; Pandey, Sudhir; Chen, Ray-Jade; Chang, Ruey-Lin; Viswanadha, Vijaya Padma; Lin, Kuan-Ho; Huang, Chih-Yang

Chen, Bih-Cheng; Hung, Meng-Yu; Wang, Hsueh-Fang; Yeh, Li-Jen; Pandey, Sudhir; Chen, Ray-Jade; Chang, Ruey-Lin; Viswanadha, Vijaya Padma; Lin, Kuan-Ho; Huang, Chih-Yang.

Afiliação

Chen BC; School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan.
Hung MY; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.
Wang HF; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Yeh LJ; Department of Nutrition, Graduate Programs of Biomedical Nutrition, Hungkuang University, Taichung, Taiwan.
Pandey S; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Chen RJ; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Chang RL; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Viswanadha VP; School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan.
Lin KH; Department of Biotechnology, Bharathiar University, Coimbatore, 641 046, India.
Huang CY; College of Medicine, China Medical University, Taichung, 40402, Taiwan.

Environ Toxicol ; 33(7): 789-797, 2018 Jul.

Article em En | MEDLINE | ID: mdl-29708300

Assuntos

Apoptose/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Chá/química; Ácido gama-Aminobutírico/farmacologia; Animais; Caspase 3/metabolismo; Ventrículos do Coração/efeitos dos fármacos; Ventrículos do Coração/metabolismo; Hipertensão/tratamento farmacológico; Hipertensão/metabolismo; Hipertensão/patologia; Fator de Crescimento Insulin-Like I/metabolismo; Masculino; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos; Ratos Endogâmicos SHR; Receptores de Somatomedina/metabolismo; Chá/metabolismo; Proteína Killer-Antagonista Homóloga a bcl-2/metabolismo; Proteína X Associada a bcl-2/metabolismo; Ácido gama-Aminobutírico/uso terapêutico

Palavras-chave

BCL2; Bak; Bax; GABA tea; apoptosis; cardiac hypertension; p-Akt

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Chá / Transdução de Sinais / Apoptose / Ácido gama-Aminobutírico Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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