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A New CoII Complex as a Bulge-Specific Probe for DNA.
Cheng, Chien-Chung; Kuo, Yen-Ning; Chuang, Kuo-Shen; Luo, Chi-Fong; Wang, Wen Jwu.
Afiliação
  • Cheng CC; Institute of Chemistry, Academia Sinica, Taipei 11529 (Taiwan), Fax: (+886) 2-27831237.
  • Kuo YN; Institute of Chemistry, Academia Sinica, Taipei 11529 (Taiwan), Fax: (+886) 2-27831237.
  • Chuang KS; Department of Chemistry, Tangkang University, Taipei (Taiwan).
  • Luo CF; Department of Chemistry, Tangkang University, Taipei (Taiwan).
  • Wang WJ; Department of Chemistry, Tangkang University, Taipei (Taiwan).
Angew Chem Int Ed Engl ; 38(9): 1255-1257, 1999 May 03.
Article em En | MEDLINE | ID: mdl-29711739
ABSTRACT
Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII (tfa)2 (happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 1999 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 1999 Tipo de documento: Article