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Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.
Bennet, Ian A; Finger, L David; Baxter, Nicola J; Ambrose, Benjamin; Hounslow, Andrea M; Thompson, Mark J; Exell, Jack C; Shahari, Nur Nazihah B Md; Craggs, Timothy D; Waltho, Jonathan P; Grasby, Jane A.
Afiliação
  • Bennet IA; Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S3 7HF, UK.
  • Finger LD; Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S3 7HF, UK.
  • Baxter NJ; Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S10 2TN, UK.
  • Ambrose B; Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester M1 7DN, UK.
  • Hounslow AM; Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S3 7HF, UK.
  • Thompson MJ; Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S10 2TN, UK.
  • Exell JC; Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S3 7HF, UK.
  • Shahari NNBM; Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S3 7HF, UK.
  • Craggs TD; Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S3 7HF, UK.
  • Waltho JP; Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S3 7HF, UK.
  • Grasby JA; Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, The University of Sheffield, Sheffield S10 2TN, UK.
Nucleic Acids Res ; 46(11): 5618-5633, 2018 06 20.
Article em En | MEDLINE | ID: mdl-29718417

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endonucleases Flap Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endonucleases Flap Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article