A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

Stern, Daniel; Weisemann, Jasmin; Le Blanc, Alexander; von Berg, Laura; Mahrhold, Stefan; Piesker, Janett; Laue, Michael; Luppa, Peter B; Dorner, Martin Bernhard; Dorner, Brigitte Gertrud; Rummel, Andreas

Stern, Daniel; Weisemann, Jasmin; Le Blanc, Alexander; von Berg, Laura; Mahrhold, Stefan; Piesker, Janett; Laue, Michael; Luppa, Peter B; Dorner, Martin Bernhard; Dorner, Brigitte Gertrud; Rummel, Andreas.

Afiliação

Stern D; Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany.
Weisemann J; Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany.
Le Blanc A; Institute for Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universität München, München, Germany.
von Berg L; Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany.
Mahrhold S; Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany.
Piesker J; Advanced Light and Electron Microscopy (ZBS 4), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany.
Laue M; Advanced Light and Electron Microscopy (ZBS 4), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany.
Luppa PB; Institute for Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Dorner MB; Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany.
Dorner BG; Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany.
Rummel A; Institut für Toxikologie, Medizinische Hochschule Hannover, Hannover, Germany.

PLoS Pathog ; 14(5): e1007048, 2018 05.

Article em En | MEDLINE | ID: mdl-29718991

Assuntos

Toxinas Botulínicas/genética; Toxinas Botulínicas/metabolismo; Animais; Sítios de Ligação; Toxinas Botulínicas Tipo A/metabolismo; Proteínas de Transporte/metabolismo; Membrana Celular/metabolismo; Cristalografia por Raios X; Gangliosídeos; Interações Hidrofóbicas e Hidrofílicas; Lipídeos; Glicoproteínas de Membrana/metabolismo; Camundongos; Ligação Proteica; Conformação Proteica; Receptores de Neurotransmissores/metabolismo; Sorogrupo; Vesículas Sinápticas

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxinas Botulínicas Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxinas Botulínicas Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article