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Pyoderma gangrenosum-like ulcerations in granulomatosis with polyangiitis: two cases and literature review.
Genovese, Giovanni; Tavecchio, Simona; Berti, Emilio; Rongioletti, Franco; Marzano, Angelo Valerio.
Afiliação
  • Genovese G; Dermatology Unit, Department of Physiopathology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Pace 9, 20122, Milan, Italy.
  • Tavecchio S; Dermatology Unit, Department of Physiopathology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Pace 9, 20122, Milan, Italy.
  • Berti E; Dermatology Unit, Department of Physiopathology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Pace 9, 20122, Milan, Italy.
  • Rongioletti F; Section of Dermatology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
  • Marzano AV; Dermatology Unit, Department of Physiopathology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Pace 9, 20122, Milan, Italy. angelo.marzano@unimi.it.
Rheumatol Int ; 38(6): 1139-1151, 2018 Jun.
Article em En | MEDLINE | ID: mdl-29721696
ABSTRACT
Granulomatosis with polyangiitis (GPA) is a systemic necrotizing small vessel vasculitis associated with circulating anti-neutrophil cytoplasmic antibodies (ANCAs). Skin manifestations, mostly represented by palpable purpura, papulonodular lesions and livedo reticularis, are present in up to 50% of the cases. Ulcerations with undermined, raised erythematous-violaceous border resembling pyoderma gangrenosum (PG) have rarely been reported as skin involvement in GPA. The presence of circulating ANCAs with a cytoplasmic labelling pattern, the involvement of internal organs, particularly of the lung, and the absence on histology of a mainly neutrophilic infiltrate in early phases of the cutaneous lesions may be regarded as clues to rule out true PG and confirm the diagnosis of GPA skin ulcerations simulating PG. Herein, we describe two paradigmatic cases of such a unique presentation of GPA and a literature review focusing on clinicopathological features of GPA presenting with PG-like ulcerations in the skin has been provided. Moreover, referring to the scenario observed in these two cases, an easy-to-use working approach for the differential diagnosis between the two conditions has also been proposed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Granulomatose com Poliangiite / Anticorpos Anticitoplasma de Neutrófilos / Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos Tipo de estudo: Diagnostic_studies / Observational_studies / Systematic_reviews Limite: Adult / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Granulomatose com Poliangiite / Anticorpos Anticitoplasma de Neutrófilos / Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos Tipo de estudo: Diagnostic_studies / Observational_studies / Systematic_reviews Limite: Adult / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article